- Title
- A system for EPID-based real-time treatment delivery verification during dynamic IMRT treatment
- Creator
- Fuangrod, Todsaporn; Woodruff, Henry C.; van Uytven, Eric; McCurdy, Boyd M. C.; Kuncic, Zdenka; O'Connor, Daryl J.; Greer, Peter B.
- Relation
- Medical Physics Vol. 40, Issue 9
- Publisher Link
- http://dx.doi.org/10.1118/1.4817484
- Publisher
- American Association of Physicists in Medicine
- Resource Type
- journal article
- Date
- 2013
- Description
- Purpose: To design and develop a real-time electronic portal imaging device (EPID)-based delivery verification system for dynamic intensity modulated radiation therapy (IMRT) which enables detection of gross treatment delivery errors before delivery of substantial radiation to the patient. Methods: The system utilizes a comprehensive physics-based model to generate a series of predicted transit EPID image frames as a reference dataset and compares these to measured EPID frames acquired during treatment. The two datasets are using MLC aperture comparison and cumulative signal checking techniques. The system operation in real-time was simulated offline using previously acquired images for 19 IMRT patient deliveries with both frame-by-frame comparison and cumulative frame comparison. Simulated error case studies were used to demonstrate the system sensitivity and performance. Results: The accuracy of the synchronization method was shown to agree within two control points which corresponds to approximately ~1% of the total MU to be delivered for dynamic IMRT. The system achieved mean real-time gamma results for frame-by-frame analysis of 86.6% and 89.0% for 3%, 3 mm and 4%, 4 mm criteria, respectively, and 97.9% and 98.6% for cumulative gamma analysis. The system can detect a 10% MU error using 3%, 3 mm criteria within approximately 10 s. The EPID-based real-time delivery verification system successfully detected simulated gross errors introduced into patient plan deliveries in near real-time (within 0.1 s). Conclusions: A real-time radiation delivery verification system for dynamic IMRT has been demonstrated that is designed to prevent major mistreatments in modern radiation therapy.
- Subject
- real-time treatment verification; EPID; intensity-modulated radiotherapy
- Identifier
- http://hdl.handle.net/1959.13/1299759
- Identifier
- uon:19934
- Identifier
- ISSN:0094-2405
- Language
- eng
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